The Art of Multiple Sequence Alignment in R
نویسنده
چکیده
Figure 1: The art of multiple sequence alignment. This document is intended to illustrate the art of multiple sequence alignment in R using DECIPHER. Even though its beauty is often concealed, multiple sequence alignment is a form of art in more ways than one. Take a look at Figure 1 for an illustration of what is happening behind the scenes during multiple sequence alignment. The practice of sequence alignment is one that requires a degree of skill, and it is that art which this vignette intends to convey. It is simply not enough to “plug” sequences into a multiple sequence aligner and blindly trust the result. An appreciation for the art as well a careful consideration of the results are required. What really is multiple sequence alignment, and is there a single correct alignment? Generally speaking, alignment seeks to perform the act of taking multiple divergent biological sequences of the same “type” and fitting them to a form that reflects some shared quality. That quality
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